Volume 3, Issue 4, August 2018, Page: 55-58
Cervical Smears: Morphological and Epidemiological Study for Intra-Epithelial Neoplasia in Lubumbashi
Mwenze Didier, Pathology Department, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo
Mulenga Phillipe, Public Health Department, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo
Mukalay Abdon, Public Health Department, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo
Ilunga Julien, Pathology Department, University of Lubumbashi, Lubumbashi, Democratic Republic of Congo
Received: Sep. 1, 2018;       Accepted: Sep. 29, 2018;       Published: Oct. 25, 2018
DOI: 10.11648/j.ijcocr.20180304.12      View  166      Downloads  5
Abstract
Cervical carcinoma is one of the most preventable cancers for conventional cervical smear may detect intra-epithelial neoplasia before the invasive stage. Often cervical intra-epithelial neoplasia may be detected by conventional cervical smear. There is no cancer control policy in the Democratic Republic of Congo (DRC), as there is no cancer registry. This study was done to determine the morphological and epidemiological profile of cervical pathology in Lubumbashi. Data were selected from the Congolese League against Cancer (LCCC) registry who organized in the Democratic Republic of Congo the first cervical voluntary screening in March 2012. In total, 639 women aged from 22 to 65 years underwent cervical smears. Histopathological examination was done in case of high grade intra-epithelial neoplasia. Among all the women, 30 were living with intra-epithelial neoplasia, 24.4 and 75.6% had high grade and low grade lesions. Cytological and histological correlation was found in 65% of high grade lesion. In conclusion, this study shows a significant frequency of intra-epithelial cervical neoplasia in Lubumbashi city. Women beyond 30 years present 11 times the risk of high grade intra-epithelial lesion compared to youngers. Data are in many cases not reproducible compared with some publications. This study calls for multicentrically evaluation of intra-epithelial cervical neoplasma and for cervical cancer.
Keywords
Cervical Screening, Intra-Epithelial Neoplasia, Cancer in Developing Countries
To cite this article
Mwenze Didier, Mulenga Phillipe, Mukalay Abdon, Ilunga Julien, Cervical Smears: Morphological and Epidemiological Study for Intra-Epithelial Neoplasia in Lubumbashi, International Journal of Clinical Oncology and Cancer Research. Vol. 3, No. 4, 2018, pp. 55-58. doi: 10.11648/j.ijcocr.20180304.12
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Parkin DM, Whelan SL, Ferlay J, Raymond L, Young J. Cancer jncidence in five Continents. Vol VII (IARC Scientific Publication N 143). International Agency for Research on Cancer: Lyon, France, 1997.
[2]
Mpiga É, Ivanga M, Koumakpayi IH, Engohan-Aloghe C, Ankély JC, Belembaogo E, et al. Intérêt de l’inspection visuelle à l’acide acétique et au soluté de Lugol avec colposcope dans le dépistage des lésions du col utérin au Gabon. Pan Afr Med J. 2015; 22(1).
[3]
Bergeron C, Cartier I, Guldner L, Lassalle M, Savignoni A, Asselain B. Lésions précancéreuses et cancers du col de l’utérus diagnostiqués par le frottis cervical, Ile-de-France, enquête Crisap, 2002. Bull Epidemiol Hebd. 2005; 2:5–6.
[4]
Dagneaux I. Cytologie cervicale: Comment améliorer la détection de cellules anormales et la qualité des frottis? Apport des techniques en milieu liquide et couche mince implications en médecine générale. Louvain Med. 2003; 122:193–202.
[5]
Dagneaux I. Cytologie cervicale en milieu liquide: intérêt en médecine générale. " La revue de la médecine générale" 2001. 2001; 185:304–79.
[6]
Schwartz D. Dépistage cytologique du cancer du col de l’utérus par prélèvement en milieu liquide [PhD Thesis]. University of Geneva; 2002.
[7]
Bergeron C. Frottis conventionnel ou milieu liquide? in Bernard Blanc. Le dépistage du cancer du col de l’utérus. 2005; 103–115.
[8]
Zeggai M, Sebiane S. Gestion des FCV (Frottis Cervicaux Vaginaux) de CHU Tlemcen [PhD Thesis]. 2014.
[9]
Huh WK, Ault KA, Chelmow D, Davey DD, Goulart RA, Garcia FA, et al. Use of primary high-risk human papillomavirus testing for cervical cancer screening: interim clinical guidance. Gynecol Oncol. 2015; 136(2):178–182.
[10]
Banza K, Kizonde J, Unga M, Muiach K, Kabila B, Kalenga MK. Cancer du col de l’utérus: problématique de la prise en charge. À Propos De. 1999; 40.
[11]
Leroy J, Gondry J. Le programme de dépistage français: historique et modalités. Dépist Cancer Col L’utérus. 2005; 69–80.
[12]
Tebeu PM, Sandjong I, Nkele N, Fokoua S, Achu P, Kouam L, et al. Lesions pre cancereuses du col uterin en zone rurale: Etude transversale. Med D’Afrique Noire. 2005;2005(52):1.
[13]
Dachez R. Intérêt des nouveaux marqueurs dans la prise en charge des lésions précancéreuses du col utérin. J Gynécologie Obstétrique Biol Reprod. 2008;37(1):S152–S154.
[14]
Koutsky LA, Holmes KK, Critchlow CW, Stevens CE, Paavonen J, Beckmann AM, et al. A cohort study of the risk of cervical intraepithelial neoplasia grade 2 or 3 in relation to papillomavirus infection. N Engl J Med. 1992;327(18):1272–1278.
[15]
Ronco G, Giorgi-Rossi P, Carozzi F, Confortini M, Dalla Palma P, Del Mistro A, et al. Efficacy of human papillomavirus testing for the detection of invasive cervical cancers and cervical intraepithelial neoplasia: a randomised controlled trial. Lancet Oncol. 2010;11(3):249–257.
Browse journals by subject